A pharmacokinetic analysis conducted by Rump concluded that Maximal concentrations of Rifampicin orMiconazole resulting from the insertion of a polyurethane catheter loaded with these antibiotics are therefore,far below the concentrations resulting from a systemic therapy with the same antimicrobial agents. Even in theworst case, the danger of selecting resistant bacterial strains seems remote because the systemic drug levels aremagnitudes of order below subinhibitory concentrations. (7)
AKSHAR PHARMA
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